Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy |
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| Authors: | Savita Bisht Georg Feldmann Sheetal Soni Rajani Ravi Collins Karikar Amarnath Maitra Anirban Maitra |
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| Institution: | (1) The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;(2) Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;(3) Department of Chemistry, University of Delhi, Delhi, India |
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| Abstract: | Background Curcumin, a yellow polyphenol extracted from the rhizome of turmeric (Curcuma longa), has potent anti-cancer properties as demonstrated in a plethora of human cancer cell line and animal carcinogenesis models.
Nevertheless, widespread clinical application of this relatively efficacious agent in cancer and other diseases has been limited
due to poor aqueous solubility, and consequently, minimal systemic bioavailability. Nanoparticle-based drug delivery approaches
have the potential for rendering hydrophobic agents like curcumin dispersible in aqueous media, thus circumventing the pitfalls
of poor solubility. |
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