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Molecular docking analysis of penta galloyl glucose with the bcl-2 family of anti-apoptotic targets
Authors:Karthick Dharmalingam  Velvizhi Dharmalingam  Satheesh Durairaj  Praveen Sharma  Selvaraj Jayaraman  Sarita Choudhary
Abstract:
Apoptosis requires cellular proteins from the B-cell lymphoma 2 (BCL-2) family linked to breast cancer. Therefore, it is of interest to document the Molecular docking analysis data of penta galloyl glucose with the bcl-2 family of anti-apoptotic targets (Bcl-2, BCL-XL, Caspase 3, and Caspase 9). Data shows that Pentagalloyl glucose have optimal binding features with Bcl-2, BCL-XL, Caspase 3, and Caspase 9 proteins with binding energy of -8.6,-7,-7.5 and 4.4 kcal/mol respectively for further consideration in this context.
Keywords:Breast cancer   apoptosis   penta galloyl glucose   molecular docking
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