细菌与秀丽隐杆线虫之间互作关系的研究进展

秀丽隐杆线虫(Caenorhabditis elegans)以其个体小、易培养、生活周期短等优势成为生物发育、衰老、神经及免疫相关机制研究的模式生物。它在实验室培养时主要靠饲喂大肠杆菌OP50,有报道,细菌及其代谢物对线虫的代谢、行为和寿命有至关重要的影响。因此,作为一个遗传模型,秀丽隐杆线虫可以帮助研究微生物与宿主相互作用的遗传基础。通过总结细菌在线虫生活史中重要作用及方式,为完善细菌-线虫模型、解析细菌-线虫相互作用的保守机理提供理论基础,并为该模型在其他物种(包括人类)治疗疾病的新策略提供新的见解。

Research progress on the interaction between bacteria and Caenorhabditis elegans

Caenorhabditis elegans has become a model organism for studying biological development,aging,neural and immune mechanisms due to its advantages of small size,easy culture and short life cycle. E. coli OP50 is its main food in laboratory,and it has been reported that bacteria and their metabolites have vital effects on its metabolism,behavior and lifespan. Therefore,as a genetic model,C. elegans can help to study the genetic basis of microbe-host interactions. By summarizing the important roles of bacteria in the life cycle of nematodes,this paper provides a theoretical basis for perfecting the bacterial-nematode model and analyzing the conservative mechanism of bacterial-nematode interactions,and also provides new insights into the potential development of new strategies for this model for the treating diseases in other species,including humans.