Synthesis,characterization and cytotoxic activities of the [RuCl2(NO)(dppp)(L)]PF6 complexes |
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| Authors: | Camilla C. Golfeto Gustavo Von Poelhsitz Heloísa S. Selistre-de-Araújo Márcio P. de Araujo Javier Ellena Eduardo E. Castellano Luiz G.L. Lopes Icaro S. Moreira Alzir A. Batista |
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| Affiliation: | 1. Departamento de Química, Universidade Federal de São Carlos, CP 676, CEP 13565-905 São Carlos, SP, Brazil;2. Departamento de Química, Universidade Federal de Goiás, Campus Catalão, CP 56, CEP 75704-020 Catalão, GO, Brazil;3. Departamento de Ciências Fisiológicas, Universidade Federal de São Carlos, CP 676, CEP 13565-905 São Carlos, SP, Brazil;4. Departamento de Química, Universidade Federal do Paraná, CP 19081, CEP 81531-980 Curitiba, PR, Brazil;5. Instituto de Física de São Carlos, Universidade de São Paulo, CP 369, CEP 13560-970 São Carlos, SP, Brazil;6. Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, CP 12200, 604 55-970 Fortaleza-CE, Brazil |
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| Abstract: | The synthesis and characterization of ruthenium compounds of the type [RuCl2(NO)(dppp)(L)]PF6 [dppp = 1,3-bis(diphenylphosphino)propane; L = pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described. The complexes were characterized by elemental analysis, UV/Vis and infrared spectroscopy, cyclic voltammetry, and X-ray crystallography for the complexes with the pyridine and 4-methylpyridine ligands. In vitro evaluation of these nitrosyl complexes revealed cytotoxic activity from 7.1 to 19.0 μM against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The 1,3-bis(diphenylphosphino)propane and the N-heterocyclic ligands alone failed to show cytotoxic activities at the concentrations tested (maximum concentration utilized = 200 μM). |
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