Ovarian development in 46,XY gonadal dysgenesis |
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| Authors: | Marcia H. Russell Stephen S. Wachtel Ben W. Davis Linda T. Cahill Erich Groos Gary D. Niblack Ian M. Burr |
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| Affiliation: | (1) Division of Genetics, Department of Pediatrics, Vanderbilt University Hospital, 37232 Nashville, TN, USA;(2) Department of Pathology, Vanderbilt University Hospital, 37232 Nashville, TN, USA;(3) Memorial Sloan-Kettering Cancer Center, 10021 New York, NY, USA;(4) Department of Pediatrics, New York Hospital-Cornell Medical Center, 10021 New York, NY, USA |
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| Abstract: | Summary In human the XY ovary is degenerative, there being scant evidence of persistence of that organ beyond the perinatal period. Here we describe indications of functional ovarian tissue in a 17-year-old female with male karyotype, H-Y+ cellular phenotype, and some signs of the Turner syndrome. Her gonads were removed after the onset of secondary amenorrhea. Histological examination revealed a degenerative right ovary devoid of germ cells and follicles, and a left streak gonad. There was no trace of testicular development in either side. |
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