Effect of serotonin on cyclic nucleotides of human platelets. |
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Authors: | K C Agarwal M Steiner |
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Institution: | Division of Hematologic Research, The Memorial Hospital and Section of Biochemical Pharmacology, Brown University Providence, Rhode Island 02912 USA |
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Abstract: | Serotonin produced a 6 to 10 fold increase of cyclic GMP over baseline levels of this nucleotide in platelets. Maximum stimulation was reached within 30 sec to 1 min after addition of serotonin and was dependent upon its concentration in the medium. Inhibition of serotonin uptake by methysergide, dihydroergotamine and chloroimipramine did not influence the serotonin-induced stimulation of cyclic GMP but glutaraldehyde and formaldehyde blocked it completely. Cyclic AMP levels in platelets were not affected by serotonin. The serotonin-induced stimulation of cyclic GMP is independent of the uptake of this biogenic amine by platelets and is not due to platelet aggregation. |
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