Effect of concanavalin A on interferon induction by poly IC |
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| Authors: | H D Harper P M Pitha |
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| Affiliation: | 1. Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland USA;2. Department of Microbiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland USA |
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| Abstract: | Concanavalin A, a plant lectin having specific membrane properties, has an inhibitory effect on interferon induction by poly IC, both in human fibroblast and mouse 3T3 cells. In the studied systems, the inhibition is independent of an effect on polynucleotide binding. |
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