Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1 |
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Authors: | Poliak Sebastian Salomon Daniela Elhanany Hadas Sabanay Helena Kiernan Brent Pevny Larysa Stewart Colin L Xu Xiaorong Chiu Shing-Yan Shrager Peter Furley Andrew J W Peles Elior |
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Institution: | Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel. |
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Abstract: | In myelinated axons, K+ channels are concealed under the myelin sheath in the juxtaparanodal region, where they are associated with Caspr2, a member of the neurexin superfamily. Deletion of Caspr2 in mice by gene targeting revealed that it is required to maintain K+ channels at this location. Furthermore, we show that the localization of Caspr2 and clustering of K+ channels at the juxtaparanodal region depends on the presence of TAG-1, an immunoglobulin-like cell adhesion molecule that binds Caspr2. These results demonstrate that Caspr2 and TAG-1 form a scaffold that is necessary to maintain K+ channels at the juxtaparanodal region, suggesting that axon-glia interactions mediated by these proteins allow myelinating glial cells to organize ion channels in the underlying axonal membrane. |
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Keywords: | axon node of Ranvier myelin cell adhesion Schwann cell |
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