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| CD15 mRNA和nm23H1 mRNA表达与结直肠癌转移和预后的关系 | |
| 引用本文： | 谷化平,尚培中,倪灿荣,詹熔洲. CD15 mRNA和nm23H1 mRNA表达与结直肠癌转移和预后的关系[J]. 中国组织化学与细胞化学杂志, 2001, 10(3): 326-329,360 |
| 作者姓名： | 谷化平 尚培中 倪灿荣 詹熔洲 |
| 作者单位： | 1. 解放军251医院病理科 2. 普通外科 3. 第二军医大学长海医院病理科 |
| 摘 要： | 为了探讨评估结直肠癌预后指标。应用催化信号放大-原位杂交技术。研究90例结直肠癌组织中CD15和nm23H1的mRNA表达，并结合随访资料分析，结果表明，在结直肠癌中CD15和nm23H1的mRNA阳性表达分别为84.4%和66.7%。CD15mRNA高表达及nm23H1mRNA低表达与结直肠癌浸润程度，淋巴结转移和肝脏转移状况密切相关，提示CD15和nm23H1的mRNA表达均可作为预测结直肠癌侵袭转移和客观评估患者预后的生物学指标。 |
| 关 键 词： | CD15 mRNA nm23H1 表达 结直肠癌 预后 腺癌 原位杂交 肿瘤转移 |
RELATIONSHIP OF CD_(15) mRNA AND nm23H1 mRNA EXPRESSION WITH METASTASIS AND PROGNOSIS IN COLORECTAL CARCINOMA |
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| Gu Huaping,Shang Piezhong,Ni Canrong,et al. RELATIONSHIP OF CD_(15) mRNA AND nm23H1 mRNA EXPRESSION WITH METASTASIS AND PROGNOSIS IN COLORECTAL CARCINOMA[J]. Chinese Journal of Histochemistry and Cytochemistry, 2001, 10(3): 326-329,360 | |
| Authors: | Gu Huaping Shang Piezhong Ni Canrong et al |
| Abstract: | To study the prognostic parameter, catalyzed signal amplification in situ hybridzation technique was used to detect the expression of CD 15 mRNA and nm23H1 mRNA in 90 cases of colorectal carcinoma. Fifty three patients were followed up. The positive rate of CD 15 mRNA and nm23H1 mRNA was 84 4% and 66 7% respectively. The high level expression of CD 15 mRNA and the low expression of nm23H1 mRNA were correlated with serosa infiltration, lymyh node and liver metastases. The results demonstrate that the expression of CD 15 mRNA and nm23H1 mRNA could be a new biological marker for predicting the invasive potential and evaluating the prognosis of patients with colorectal carcinoma. |
| Keywords: | Colorectal carcinoma Adenocarcinoma CD 15 mRNA nm23H1 mRNA In situ hybridization |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |