A novel type of human alpha-amylase produced in lung carcinoid tumor |
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| Authors: | N Tomita A Horii S Doi H Yokouchi K Shiosaki M Higashiyama N Matsuura M Ogawa T Mori K Matsubara |
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| Institution: | Institute for Molecular and Cellular Biology, Osaka University, Japan. |
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| Abstract: | A novel type of alpha-amylase was detected in a lung carcinoid tissue after surveying the cDNA library constructed from this tumor mRNA. Nucleotide sequence analysis showed that the amylase expressed in this carcinoid tumor has 13 and 6 amino acid substitutions when compared with salivary amylase (Amy1) and pancreatic amylase (Amy2), respectively. The nucleotide sequence homologies of cDNAs between this carcinoid amylase and amy1, amy2 are 97.5% and 98.2%, respectively. The nucleotide sequence comparison strongly suggests that this new amylase is the product of the amy3 gene that has been detected in human genome Emi et al., Gene 62 (1988) 229-235] |
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