SERP1 prevents hypoxia-reoxygenation-induced H9c2 apoptosis through activating JAK2/STAT3 pathway-dependent attenuation of endoplasmic reticulum stress |
| |
| Authors: | Liang Shang Pingshuan Dong Laijing Du Xuming Yang Honglei Wang Shangyang Li |
| |
| Affiliation: | 1. The First Affiliated Hospital, Collage of Clinical Medicine of Henan University of Science and Technology, Luoyang, 471003, China;2. Department of Cardiology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, 471003, China;3. Department of Surgery, Luoyang New District People''s Hospital, Luoyang, Henan, 471003, China |
| |
| Abstract: | The endoplasmic reticulum (ER) stress plays an important role in myocardial ischemia/reperfusion (MI/R) injury. SERP1, the stress-associated endoplasmic reticulum protein 1, is involved in regulating ER stress response. However, whether it associates with MI/R injury is not identified. Here, we show that SERP1 is induced in the mouse heart after MI/R injury as well as in H9c2 cells under hypoxia/reoxygenation (H/R) treatment. Additionally, SERP1 overexpression reduces H/R-induced H9c2 apoptosis. Moreover, SERP1 overexpression suppresses H/R-induced ER stress and activates JAK2/STAT3 pathway. Furthermore, JAK2/STAT3 pathway inhibition by the specific inhibitor JSI-124 minimizes the suppressive effect of SERP1 overexpression on H/R-induced ER stress and H9c2 apoptosis. Together, these results uncover the protection of SERP1 against H/R-induced H9c2 apoptosis and further relate it to JAK2/STAT3 pathway-dependent attenuation of ER stress. This study suggests SERP1 as a potential regulator invovled in the pathophysiology of MI/R injury. |
| |
| Keywords: | SERP1 Hypoxia-reoxygenation Apoptosis Endoplasmic reticulum stress JAK2/STAT3 pathway |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
