Chemical speciation in wound fluid leading to enhanced bioavailability for healing期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Chemical speciation in wound fluid leading to enhanced bioavailability for healing

Authors:	Janitha A. Liyanage David M. Taylor David R. Williams

Affiliation:	Department of Chemistry, University of Wales, Cardiff, PO Box 912, Cardiff CF1 3TB, UK.

Abstract:	ABSTRACT ECCLES computer modelling is used to speciate Ca²⁺, Zn²⁺, Cu²⁺, Mn²⁺ and Fe³⁺ in wound fluid samples analysed for total metal content using Potentiometric stripping analysis. Bioavailability of metals, related to lipid soluble net-neutral complexes, was assessed and found to be broadly similar to the speciation in blood plasma. These appear to be benefits worthy of clinical investigation of keeping the wound fluid at pH = 6.4 and of raising the total cysteine concentration levels in wound fluid.

Keywords:	Wound management healing