Age-dependent changes in metallothionein levels in liver and kidney of the Japanese |
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| Authors: | Minoru Yoshida Hisayoshi Ohta Youji Yamaguchi Yukio Seki Morihisa Sagi Kentarou Yamazaki Yawara Sumi |
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| Institution: | (1) Department of Chemistry, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511 Kawasaki, Japan;(2) Department of Occupational Health and Toxicology, School of Allied Health Science, Kitasato University, 1-15-1, Kitasato, 228 Sagamihara, Japan;(3) Department of Legal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, 216-8511 Kawasaki, Japan |
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| Abstract: | Samples of liver, renal cortex, and medulla were obtained from 55 forensic autopsies (0- to 95-yr-old Japanese). Metallothionein
(MT) was determined by the Ag-hem or Cd-hem method. Zinc (Zn), copper (Cu), and cadmium (Cd) were determined by atomic absorption
spectrophotometry. The mean levels of MT were 250 μg/g in the liver, and 394 μg/g (cortex) and 191 μg/g (medulla) in the kidney.
Age-dependent changes were observed in both the liver and kidney. In the liver, MT level decreased during infancy and increased
thereafter with age. Similar age-dependent changes in the levels of Zn and Cu were observed. In the kidney cortex, MT level
increased with age, although no correlation was found after middle age. The levels of Cd and Zn also increased with age until
middle age; however, they decreased thereafter. These results suggest that age-dependent changes in renal MT levels are associated
with accumulation of Cd. |
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| Keywords: | Metallothionein cadmium zinc copper liver kidney human Japanese |
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