Exaggeration of Postprandial Hyperglycemia in Patients with type 2 Diabetes by Administration of Caffeine in Coffee |
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| Institution: | 1. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina.;2. Duke University School of Medicine, Durham, North Carolina.;3. Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, North Carolina.;1. Department of Hygiene and Preventive Medicine, Iwate Medical University, Japan;2. Department of Preventive Medicine and Public Health, Keio University, Tokyo, Japan;3. Department of Neurosurgery, Iwate Medical University, Morioka, Japan;4. Department of Urology, Iwate Medical University, Morioka, Japan;5. Department of Community Health Sciences, University of Calgary, Canada;6. Department of Nutritional Sciences, Morioka University, Takizawa, Japan;7. Department of Internal Medicine, Iwate Medical University, Morioka, Japan;8. Department of Clinical Nursing, Shiga University of Medical Science, Otsu, Japan;9. Department of Health and Physical Education, Faculty of Education, Iwate University, Morioka, Japan;10. Iwate Health Service Association, Morioka, Japan;11. The Research Institute of Strategy for Prevention, Tokyo, Japan;2. Department of Cardiothoracic Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands |
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| Abstract: | ObjectiveTo test whether caffeine administered in coffee increases postprandial hyperglycemia in patients with type 2 diabetes who are habitual coffee drinkers.MethodsThe study used a within-subject, double-blind, placebo-controlled experimental design. Twenty adult coffee drinkers (11 women and 9 men) with type 2 diabetes treated with diet, exercise, orally administered antidiabetic agents, or some combination of these factors completed two mixed-meal tolerance tests (MMTT) after an overnight fast. Before the MMTT, each study participant received 250 mg of caffeine in 16 oz (475 mL) of decaffeinated coffee or decaffeinated coffee alone, with the treatment order counterbalanced in the group. Fasting and 1-hour and 2-hour postprandial blood samples were collected for measurement of plasma glucose and insulin concentrations.ResultsGlucose and insulin responses to the MMTT were quantified by the incremental areas under the 2-hour concentration-time curves (AUC2h). Administration of caffeine in decaffeinated coffee increased postprandial glucose and insulin responses (both P = 0.02). The mean plasma glucose AUC2h was 28% larger and the mean plasma insulin AUC2h was 19% larger after administration of caffeine than after administration of placebo.ConclusionOther constituents in coffee did not prevent the exaggeration of postprandial hyperglycemia by caffeine in these patients with type 2 diabetes, who were habitual coffee drinkers. Repeated on a daily basis, such effects could impair long-term glucose control in those patients with type 2 diabetes who habitually drink coffee or other caffeinated beverages. (Endocr Pract. 2007;13: 239-243) |
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