泌尿生殖道分泌物支原体培养临床分析

探讨泌尿生殖道分泌物支原体培养的临床意义.取泌尿生殖道感染的男性尿拭子和女性宫颈分泌物1 095份进行支原体培养和药敏试验,根据药敏结果进行治疗及疗效观察.1095例患者中支原体阳性365例(33.3％),其中解脲脲原体(Ureaplasma urealyticum,Uu)感染287例,人型支原体(Mycoplasma hominis,Mh)感染55例,Uu与Mh混合感染23例.药敏试验结果显示对强力霉素、米诺环素敏感率分别为90.4％和88.8％.对林可霉素、诺氟沙星、氧氟沙星的耐药率分别为86.8％、82.5％、81.1％.男性患者根据药敏结果分别进行强力霉素和米诺环素单药治疗,其治愈率为79.5％、76.9％,女性患者联合干扰素栓剂治疗,治愈率达83.6％和82.2％.鉴于泌尿生殖道分泌物支原体的高感染率以及并不理想的临床治愈率,广泛应用分泌物支原体培养法值得商榷.

Clinical Significance to Cultivate Mycoplasma from Excretion in Urogenital Tract

The clinical significance to cultivate Mycoplasm from excretion in urogenital tract was investigated. Urinary swabs and cervical secretions from 1 095 cases of genito-urinary infected male and female patients were taken separate- ly to cultivate Mycoplo~sm and test for their drug sensitivity, and carry out treatment according to drug sensitive results and observe the curative effect. The results showed that 365 cases （33.3%） out of 1 095 cases were Mycoplasma pos- itive, among them 287 cases were Ureaplasma urealytium （ Uu ） positive ; 55 cases were Mycoplasma hominis （ Mh ） positive and 23 cases were Uu and Mn mixed-infected. Drug sensitivity test results （DSTR） showed that the sensitive rate of doxycyline and minocycline was 90.4% and 88.8% respectively. The resistance rates of lincomycin, nofloxa- cin, and ofloxacin were 86.8%, 82.5% , and 81.1% respectively. According to the DSTR, male patients were trea- ted with single drug of doxycyline and ininocycline with 79.5% and 76.9% cure rate respectively, female patients were treated combined with interferon suppository, with 83.6% and 82.2% cure rate. Therefore, in view of the high infective rate of and not optimum of clinical cure rate against genito-urinary secretion Mycoplasm, the extensive appli- cation of secretion Mycoplasm cultivation method is open to question.