Axonal degeneration is blocked by nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons |
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Authors: | Sasaki Yo Milbrandt Jeffrey |
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Institution: | Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA. |
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Abstract: | Axonal degeneration is an early and important component of many neurological disorders. Overexpression of nicotinamide mononucleotide adenylyltransferase (Nmnat), a component of the slow Wallerian degeneration (Wld(s)) protein, protects axons from a variety of insults. We found that transduction of Nmnat protein into severed axons via virus-like particles prevented axonal degeneration. The post-injury efficacy of Nmnat indicates that its protective effects occur locally within the axon and provides an opportunity to develop novel agents to treat axonal damage. |
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Keywords: | Axon NAD Neurobiology Neurological Diseases Virus Assembly Wallerian Degeneration Axonopathy Axotomy |
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