Decitabine augments cytotoxicity of cisplatin and doxorubicin to bladder cancer cells by activating hippo pathway through RASSF1A |
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Authors: | Madhuram Khandelwal Vivek Anand Sandeep Appunni Amlesh Seth Prabhjot Singh Sandeep Mathur Alpana Sharma |
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Institution: | 1.Brain Korea 21 PLUS Project for Medical Science,Yonsei University,Seoul,Republic of Korea;2.Department of Integrated Omics for Biomedical Sciences,Yonsei University,Seoul,Republic of Korea;3.Department of Cardiology, CHA Bundang Medical Center,CHA University,Seongnam,Republic of Korea;4.Institute for Bio-Medical Convergence, College of Medicine,Catholic Kwandong University,Gangneung,Republic of Korea;5.Catholic Kwandong University International St. Mary’s Hospital,Incheon,Republic of Korea |
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Abstract: | During the past decade, microRNAs have continuously been suggested as a promising therapeutic tool due to their beneficial effects, such as their multi-targets and multi-functions in pathologic conditions. As a pathologic phenotype is generally regulated by multiple signaling pathways, in this study we identified a microRNA regulating multiple target genes within cardiac hypertrophic signaling pathways. microRNA-133a is known to play a crucial role in cardiac hypertrophy. However, the role of microRNA-133a, which may regulate several signaling pathways in norepinephrine-induced cardiac hypertrophy via multi-targeting, has not been investigated. In the current study, we showed that microRNA-133a can protect cardiomyocyte hypertrophy against norepinephrine stimulation in neonatal rat ventricular cardiomyocytes via new targets, PKCδ and Gq, all of which are related to downstream signaling pathways of the α1-adrenergic receptor. Taken together, these results suggest the advantages of the therapeutic use of microRNAs as an effective potential drug regulating multiple signaling pathways under pathologic conditions. |
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