Developmentally regulated alternative splicing of brain myelin-associated glycoprotein mRNA is lacking in the quaking mouse |
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| Authors: | N Fujita S Sato T Kurihara T Inuzuka Y Takahashi T Miyatake |
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| Institution: | Department of Neurology, Niigata University, Japan. |
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| Abstract: | Evidence is presented that expression of the two myelin-associated glycoprotein mRNAs is developmentally regulated in mouse brain. In quaking mouse, the mRNA without a 45-nucleotide exon portion was scarcely expressed throughout development. We conclude that the mechanism of splicing out the 45-nucleotide exon portion is lacking in quaking mouse. |
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