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Use of a bioassay to evaluate the toxicity of beauvericin to bacteria
Authors:Castlebury  L.A.  Sutherland  J.B.  Tanner  L.A.  Henderson  A.L.  Cerniglia  C.E.
Affiliation:(1) Systematic Botany and Mycology Laboratory, U.S. Department of Agriculture, Agricultural Research Service, Beltsville, MD, 20705, U.S.A;(2) Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, 72079, U.S.A
Abstract:
An agar diffusion bioassay was used to compare the sensitivities of bacteria to the mycotoxin beauvericin. Bacillus pumilus LACB101 was inhibited by filter-paper disks containing 0.1 mgrg of beauvericin; B. cereus, B. mycoides, B. sphaericus, Paenibacillus alvei, P. azotofixans, P. macquariensis, and P. pulvifaciens by 1 mgrg; and P. validus by 25 mgrg. The anaerobes Eubacterium biforme, Peptostreptococcus anaerobius, P. productus, Bifidobacterium adolescentis, and Clostridium perfringens were also inhibited by beauvericin.
Keywords:Anaerobes  bacteria  beauvericin  bioassay  mycotoxins
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