Synthesis and evaluation of the antimalarial,anticancer, and caspase 3 activities of tetraoxane dimers |
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| Authors: | Richard K. Amewu James Chadwick Afthab Hussain Somnath Panda Rinki Rinki Omar Janneh Stephen A. Ward Candel Miguel Hollie Burrell-Saward Livia Vivas Paul M. O’Neill |
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| Affiliation: | 1. Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK;2. Department of Biomolecular & Sport Sciences, Coventry University, Priory Street, Coventry CV1 5FB, UK;3. Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK;4. Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK;5. Division of Biomedical Sciences, St George’s University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK |
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| Abstract: | ![]()
The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC50s versus colon (HT29-AK and leukemia (HL60) cell lines. |
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| Keywords: | Malaria Leukaemia Apoptosis |
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