1. Structural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Spain;2. Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA;3. IKERBASQUE, Basque Foundation for Science, 48011 Bilbao, Spain