Phylogenetic and regulatory region analysis of <Emphasis Type="Italic">Wnt5</Emphasis> genes reveals conservation of a regulatory module with putative implication in pancreas development |
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| Authors: | Maria Kapasa Stilianos Arhondakis Sophia Kossida |
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| Institution: | (1) Bioinformatics & Medical Informatics Team, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece;(2) Developmental Biology Laboratory, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece;(3) Department of Pharmacy, School of Health Sciences, University of Patras, GR-26500 Rion-Patras, Greece |
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| Abstract: | Background
Wnt5 genes belong to the large Wnt family, encoding proteins implicated into several tumorigenic and developmental processes. Phylogenetic analyses showed that
Wnt5 gene has been duplicated at the divergence time of gnathostomata from agnatha. Interestingly, experimental data for some
species indicated that only one of the two Wnt5 paralogs participates in the development of the endocrine pancreas. The purpose of this paper is to reexamine the phylogenetic
history of the Wnt5 developmental regulators and investigate the functional shift between paralogs through comparative genomics. |
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