Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor,on osteoclasts and collagen-induced arthritis in mice |
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| Authors: | Shoko Toyama Naoto Tamura Kazuhiko Haruta Takeo Karakida Shigeyuki Mori Tetsuo Watanabe Takao Yamori Yoshinari Takasaki |
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| Institution: | (1) Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan;(2) Central Research Laboratory, Zenyaku Kogyo Co., Ltd, 2-33-7 Oizumimachi, Nerima-ku, Tokyo 178-0062, Japan;(3) Department of Biochemistry, School of Dental Medicine, Tsurumi University, 2-1-3 Tsurumi, Tsurumi-ku, Yokohama Kanagawa, 230-8501, Japan;(4) Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan |
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| Abstract: | Introduction Targeting joint destruction induced by osteoclasts (OCs) is critical for management of patients with rheumatoid arthritis
(RA). Since phosphoinositide 3-kinase (PI3-K) plays a critical role in osteoclastogenesis and bone resorption, we examined
the effects of ZSTK474, a novel phosphoinositide 3-kinase (PI3-K)-specific inhibitor, on murine OCs in vitro and in vivo. |
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