Legumain在恶性肿瘤中的研究现状

Legumain是一种溶酶体半胱氨酸蛋白酶,是半胱氨酸蛋白酶C13家族的新成员.研究表明,Legumain作为一种应激性蛋白,在多种实体瘤、肿瘤相关巨噬细胞(TAMs)、肿瘤新生血管的内皮细胞中高表达,与恶性肿瘤的血管生成、肿瘤侵袭、扩散和转移密切相关,是近年来备受关注的一类靶标蛋白酶.对Legumain的深入研究将有利于阐明恶性实体瘤的发病机制,明确其作为肿瘤基因治疗新靶标的有效性.

Progresses on Legumain in Malignant Tumors

The Legumain is a lysosomal proteinase belonging to a novel member of the C13 family of cys-teine proteases.Legumain,as a stress protein,has been reported to be overexpressed in the majority of hu-man solid tumors,particularly in tumor-associated macrophages(TAMs) and tumor endothelial cells.Its over-expression is believed to associated with malignant tumor invasion,proliferation and metastasis,which makes Legumain attract much attention recently,as a candidate enzymatic target.Further studies on Legumain may provide us new insights into pathopaysiology processes of solid tumors,and help us evaluate its efficacy as a promising biomarker for cancer gene therapy.