Phylogenetic classification of transporters and other membrane proteins from Saccharomyces cerevisiae |
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| Authors: | De Hertogh Benoît Carvajal Elvira Talla Emmanuel Dujon Bernard Baret Philippe Goffeau André |
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| Institution: | (1) Unité de Génétique, Faculté d'Agronomie, Université Catholique de Louvain, Louvain-la-Neuve, Belgium,;(2) Instituto de Biologia Roberto Alcantara Gomes, Universidade Estado Rio de Janeiro, Brazil,;(3) Unité de Génétique Moléculaire des Levures, Institut Pasteur and Université Pierre et Marie Curie, Paris, France,;(4) Chaire Internationale de Recherche Blaise Pascal, Laboratoire de Génétique Moléculaire, Ecole Normale Supérieure, Paris, France, |
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| Abstract: | On the basis of functional and phylogenetic criteria, we have identified a total of 229 subfamilies and 111 singletons predicted
to carry out transport or other membrane functions in Saccharomyces cerevisiae. We have extended the Transporter Classification (TC) and created a Membrane Classification (MC) for non-transporter membrane
proteins. Using the preliminary phylogenetic digits X, Y, Z (for new families, subfamilies, and clusters, respectively), we
allocated a five-digit number to 850 proteins predicted to contain more than two transmembrane domains. Compared with a previous
TC of the yeast genome, we classified an additional set of 538 membrane proteins (transporters and non-transporters) and identified
111 novel phylogenetic subfamilies.
Electronic Publication |
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| Keywords: | Phylogenetic classification Yeast Membrane proteins Transporters |
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