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Genome Sequences of Three Live Attenuated Vaccine Strains of Brucella Species and Implications for Pathogenesis and Differential Diagnosis
Authors:Yufei Wang  Yuehua Ke  Zhoujia Wang  Xitong Yuan  Yefeng Qiu  Qing Zhen  Jie Xu  Tiefeng Li  Dali Wang  Liuyu Huang  Zeliang Chen
Abstract:Live attenuated vaccines play essential roles in the prevention of brucellosis. Here, we report the draft genome sequences of three vaccine strains, Brucella melitensis M5-10, B. suis S2-30, and B. abortus 104M. Primary genome sequence analysis identified mutations, deletions, and insertions which have implications for attenuation and signatures for differential diagnosis.
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