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Genetics of Ia-like alloantigens in chickens and linkage withB major histocompatibility complex |
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| Authors: | Donald L Ewert Douglas G Gilmour W Elwood Briles Max D Cooper |
| Institution: | (1) The Cellular Immunobiology Unit of the Tumor Institute, Departments of Pediatrics and Microbiology, and The Comprehensive Cancer Center, University of Alabama in Birmingham, 35294 Birmingham, Alabama;(2) Department of Microbiology, New York University School of Medicine, 10016 New York, New York;(3) Department of Biological Sciences, Northern Illinois University, 60115 De Kalb, Illinois |
| Abstract: | Two sets of backcross matings were performed to test for linkage between genes coding for the Ia-like antigens ( Ia ) and the B erythrocyte antigens (Ea-B) of the chicken. Evidence is presented which indicates that the la antigens are determined by a single codominant locus and that theEa-B and Ia loci are on the same chromosome. Failure to detect a single recombinant between theEa-B and Ia loci out of 208 progeny suggests close linkage of the two genes with a map distance of up to about 2 centimorgans. The Ia genes are thus included in theB major histocompatibility complex of the chicken. |
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