An algorithm for the determination and quantification of components of nucleic acid mixtures based on single sequencing reactions |
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Authors: | Alexander Pozhitkov Kathryn Stemshorn Diethard Tautz |
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Affiliation: | (1) Institut fr Genetik, der Universitt zu Kln, Zlpicherstrasse 47, 50674 Kln, Germany;(2) Civil and Environmental Engineering, University of Washington, Seattle, 98195, WA, USA |
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Abstract: | Background Determination and quantification of nucleic acid components in a mixture is usually accomplished by microarray approaches,
where the mixtures are hybridized against specific probes. As an alternative, we propose here that a single sequencing reaction
from a mixture of nucleic acids holds enough information to potentially distinguish the different components, provided it
is known which components can occur in the mixture. |
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Keywords: | |
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