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An algorithm for the determination and quantification of components of nucleic acid mixtures based on single sequencing reactions
Authors:Alexander Pozhitkov   Kathryn Stemshorn  Diethard Tautz
Affiliation:(1) Institut fr Genetik, der Universitt zu Kln, Zlpicherstrasse 47, 50674 Kln, Germany;(2) Civil and Environmental Engineering, University of Washington, Seattle, 98195, WA, USA
Abstract:

Background  

Determination and quantification of nucleic acid components in a mixture is usually accomplished by microarray approaches, where the mixtures are hybridized against specific probes. As an alternative, we propose here that a single sequencing reaction from a mixture of nucleic acids holds enough information to potentially distinguish the different components, provided it is known which components can occur in the mixture.
Keywords:
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