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| 谷氨酸对大鼠海马CA1区神经元的短暂性外向K+电流的影响 | |
| 作者姓名： | Xu CQ Zhang ZM Xia ZL Wu CH Zhou PA |
| 作者单位： | 1. 广东省江门市中心医院神经内科,江门,529071 2. 北京医科大学附属第三医院外科,北京,100083 3. 泰山医学院附属医院老年病科,泰安,271000 4. 北京大学生物膜与膜生物工程国家开放实验室,北京,100871 |
| 基金项目： | 山东省自然科学青年基金 |
| 摘 要： | 为了在离子通道水平探讨谷氨酸对急性分离海马ＣＡ１区神经元的短暂外向Ｋ＋电流的影响。用７～１０ｄ大鼠,以链霉蛋白酶Ｅ酶解加吸管吹打法制备海马ＣＡ１区神经元;利用全细胞膜片箝技术,观察了谷氨酸对海马ＣＡ１区锥体细胞的短暂性Ｋ＋电流的影响。结果观察到谷氨酸对短暂性Ｋ＋电流有明显抑制作用,且呈明显浓度依赖性、时间依赖性和部分电压依赖性。上述结果表明,谷氨酸对Ｋ＋通道的影响在中枢神经系统中具有重要作用。 |
| 关 键 词： | 谷氨酸 海马 神经元 电生理学 |
Effects of glutamate on transient outward potassium current of dissociated hippocampal neurons in ca1 sector in rats |
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| Xu CQ,Zhang ZM,Xia ZL,Wu CH,Zhou PA.Effects of glutamate on transient outward potassium current of dissociated hippocampal neurons in ca1 sector in rats[J].Acta Physiologica Sinica,1999,51(1):55-59. | |
| Authors: | Xu C Q Zhang Z M Xia Z L Wu C H Zhou P A |
| Institution: | Department of Neurology, Central Hospital of Jiangmen District, Jiangmen 529071. |
| Abstract: | The effects of glutamate on the transient outward potassium current of dissociated hippocampal CA(1) neurons of 7-10 d rats were studied by the whole-cell patch clamp technique. It was found that glutamate could block the transient potassium current in a dose- and time-dependent manner. The effect was partly voltage-dependent. These results suggest that glutamate may decrease the membrane conductance of K(+) channels in hippocampal neurons. |
| Keywords: | glutamate hippocampus neurons electrophysiology |
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