| 环状RNA与人类疾病 |
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| 引用本文： | 付丽云,胡耀仁,郭俊明.环状RNA与人类疾病[J].中国生物化学与分子生物学报,2015,31(8):771-778. |
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| 作者姓名： | 付丽云 胡耀仁 郭俊明 |
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| 作者单位： | （1）宁波大学医学院生物化学与分子生物学研究所 浙江省病理生理学技术研究重点实验室,宁波 315211;2）宁波市第二医院肝病科,宁波315020） |
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| 基金项目： | 国家自然科学基金资助项目(No.81171660),浙江省自然科学基金项目(No. LY14C060003), 浙江省公益类应用研究项目(No. 2014C33222), 浙江省区域专病中心建设学科项目(No. 201498),宁波市临床特色重点专科项目(No.201388), 宁波市自然科学基金项目（No.2015A610236）和浙江省病理生理学技术研究重点实验室开放基金(No.201501)资助 |
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| 摘 要： | 环状RNA(circular RNAs,circRNAs)是一类广泛存在于各种生物细胞中具有调控基因表达功能的非编码RNA,具有结构稳定和组织特异性表达等特征.有些circRNA分子富含微小RNA结合位点,可通过充当竞争性内源RNA的角色来发挥作用,如CDR1as对miR-7的海绵作用与肺癌、乳腺癌、胶质瘤及肌萎缩性脊髓侧索硬化等疾病发生相关.c ANRIL可通过影响多梳家族参与动脉粥样硬化的发生.大量circRNA的发现及其结构和功能的阐明不仅可以使我们更加深入地了解疾病的发生机制,而且为相关疾病的预防、诊断和治疗提供了新的方向.
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| 关 键 词： | 环状RNA 竞争性内源RNA 微小RNA海绵 基因表达调控 |
| 收稿时间： | 2015-01-14 |
CircRNAs and Human Diseases |
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| FU Li-Yun,HU Yao-Ren,GUO Jun-Ming.CircRNAs and Human Diseases[J].Chinese Journal of Biochemistry and Molecular Biology,2015,31(8):771-778. |
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| Authors: | FU Li-Yun HU Yao-Ren GUO Jun-Ming |
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| Institution: | (1) Department of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Zhejiang Key Laboratory of Pathophysiology, Ningbo 315211, China; 2) Department of Hepatology, Ningbo No.2 Hospital, Ningbo 315020, China) |
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| Abstract: | Circular RNAs (circRNAs) represent a class of wide spread non-coding RNAs that regulate gene expression. They share a stable structure and tissue-specific expression and other features. Harboring microRNAs (miRNAs) competition sites, some circRNAs may act as competing endogenous RNAs. For example, CDR1as sponging miR-7 is related with pathogenesis of lung cancer, breast cancer, glioma, and amyotrophic lateral sclerosis etc. cANRIL affects atherosclerosis through Polycomb protein family members. With an overwhelming number of identified circRNAs in humans, in-depth study of the structure and function of circRNAs may not only push us to disclose mechanisms of some diseases, but also provide a new direction for the prevention, diagnosis and treatment of disorders. |
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| Keywords: | circular RNAs competing endogenous RNA microRNA sponge gene expression regulation |
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