Inhibition of prostaglandin E2-induced cyclic AMP accumulation in the rat anterior pituitary by 11-deoxyprostaglandin E analogs (9-ketoprostynoic acids) |
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Authors: | W Lippmann |
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Institution: | Biochemical Pharmacology Department Ayerst Laboratories Montreal, Quebec, Canada |
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Abstract: | The effects of various 11-deoxyprostaglandin E analogs on the basal and prostaglandin E2 (PGE2)-induced cyclic AMP accumulation in the rat anterior pitutiary were studied
. 13-Hydroxy-9-oxoprost-14-ynoic acid at 5 × 10−4M, but not 5 × 10−5M, decreased (45%) the induced accumulation and did not alter the basal accumulation; 15-hydroxy-9-oxoprost-13-ynoic acid at 5 × 10−4M caused less of a decrease (29%) in the induced and also did not alter the basal accumulation. (14Z)-13-Hydroxy-9-oxoprost-14-enoic acid at 5 × 10−4M did not alter the induced and caused a slight increase (5 fold) in the basal accumulation. 7-Oxa-13-prostynoic acid increased slightly the basal accumulation at 5 × 10−5M (2 fold) and 2.33 × 10−4M (6 fold) and did not antagonize the induced accumulation. Thus, the 9-ketoprostynoic acids are effective PGE2 antagonists in this system. |
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