Insulin and glucagon immunoreactivity during high-intensity exercise under opiate blockade |
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Authors: | Theodore J Angelopoulos Robert J Robertson F L Goss and Allan Utter |
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Institution: | (1) Laboratory of Applied Physiology, The University of Southern Mississippi, Box 5142, Hattiesburg, MS39406, USA, US;(2) Human Energy Research Laboratory, University of Pittsburgh, Pittsburgh, PA 15261, |
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Abstract: | Eight fit men maximum oxygen consumption (O2max) 64.6 (1.9) ml · kg−1 · min−1, aged 28.3 (1.7) years (SE in parentheses) were studied during two treadmill exercise trials to determine the effect of endogenous
opioids on insulin and glucagon immunoreactivity during intense exercise (80% O2max). A double-blind experimental design was used with subjects undertaking the two exercise trials in counterbalanced order.
Exercise trials were 20 min in duration and were conducted 7 days apart. One exercise trial was undertaken following administration
of naloxone (N; 1.2 mg; 3 ml) and the other after receiving a placebo (P; 0.9% NaCl saline; 3 ml). Prior to each experimental
trial a flexible catheter was placed into an antecubital vein and baseline blood samples were collected. Immediately after,
each subject received either a N or P bolus injection. Blood samples were also collected after 20 min of continuous exercise
(running). Glucagon was higher (P < 0.05), while insulin was lower (P < 0.05), during exercise compared with pre-exercise values in both trials. However, glucagon was higher (P < 0.05) in the P than in the N exercise trial 141.4 (8.3) ng · l−1 vs 127.2 (7.6) ng · l−1]. There were no differences in insulin during exercise between the P and N trials 50.2 (4.3) pmol · l−1 vs 43.8 (5) pmol · l−1]. These data suggest that endogenous opioids may augment the glucagon response during intense exercise.
Accepted: 15 June 1996 |
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Keywords: | Opioids Glucagon Insulin Naloxone Physical activity |
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