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Relationship between computerized morphonuclear image analysis and histopathologic grading of breast cancer
Authors:D Larsimont  R Kiss  D d'Olne  Y de Launoit  W Mattheiem  R Paridaens  J L Pasteels  A Verhest
Affiliation:Department of Anatomic Pathology, Jules Bordet Institute, Brussels, Belgium.
Abstract:
A pilot study analyzed the relationship between several morphonuclear parameters and the Bloom-Richardson score for 37 invasive, not-otherwise-specified (NOS) ductal breast carcinomas. The SAM-BA 200 cell image processor and its software were used to measure the nuclear features on Feulgen-stained imprint smears. Two parameters representing the numbers of large and dense chromatin clots and two parameters describing the heterogeneity of the chromatin among nuclei in a specimen evolved in a continuous manner parallel with the Bloom-Richardson score from stages NOS-4 to NOS-8. The systematic measurement of these four parameters on a large series of breast cancers may be able to define an objective and reproducible "scale" of differentiation that could be a helpful tool for pathologists and clinicians.
Keywords:
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