| 线粒体DNA缺失与神经肌肉性疾病的研究 |
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| 引用本文： | 张丽珊,黄鹰,李方园,王世浚,陈金东,郑谷,陈诒ZHANG Li-Shan,HUANG Ying,LI Fang-Yuan,WANG Shi-Jun,CHEN Jin-Dong,ZHENG Gu.线粒体DNA缺失与神经肌肉性疾病的研究[J].遗传,1995,17(2):4-6. |
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| 作者姓名： | 张丽珊 黄鹰 李方园 王世浚 陈金东 郑谷 陈诒ZHANG Li-Shan HUANG Ying LI Fang-Yuan WANG Shi-Jun CHEN Jin-Dong ZHENG Gu |
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| 作者单位： | 1.南京铁道医学院生物学教研室,南京 210009
2.南京市脑科医院病理科，南京 210029
1.Department of Biology,Nanjing Railway Medical College,Nanjing 210009
2.Department of Pathology,Nanjing Brain Hospital 210029 |
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| 摘 要： | 应用PCR技术对13例神经肌肉疾病患者的线粒体DNA缺失进行了研究。结果表明,其中二例肢带型肌营养不良症患者骨骼肌组织和一例帕金森氏病患者的血细胞线粒体DNA中存在至少526bp的缺失。提示线粒体突变在一些神经肌肉性疾病的发生中起一定的作用。
Abstract: Using PCR technique,we analysed the skeletal muscle and blood of 13 patients with neuromuscular disaeases.The results show that a mutant mitochondrial DNA with at least 526bp deletion exits in the skeletal muscles of 2 patients with Erb muscular dystrophy and in the blood of a patients with Parkinson’s disease.From our results,mitochondrial DNA mutations could be an important contributory factor to neuromuscular diseases.
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| 关 键 词： | 线粒体DNA 缺失 Deletion Mitochondrial DNA 神经肌肉性疾病 Key words 藏族 皮纹学 跖纹主线 拉萨郊区 |
Mitochondrial DNA Deletion Associated with Neuromuscular Diseases |
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| ZHANG Li-Shan,HUANG Ying,LI Fang-Yuan,WANG Shi-Jun,CHEN Jin-Dong.Mitochondrial DNA Deletion Associated with Neuromuscular Diseases[J].Hereditas,1995,17(2):4-6. |
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| Authors: | ZHANG Li-Shan HUANG Ying LI Fang-Yuan WANG Shi-Jun CHEN Jin-Dong |
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| Abstract: | |
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| Keywords: | The suburbs of I hasa Tibetans Dermatoglyphics Plantar main line |
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