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DNA Replication and the Stability of Cell Differentiation
Authors:M. L. Pall
Affiliation:Program in Genetics and Program in Biochemistry and Biophysics, Washington State University, Pullman, Washington 99163, U.S.A.
Abstract:DNA replication may produce unoccupied regulatory binding sites on DNA. Such unoccupied sites can disrupt regulatory stability after replication has been completed. A mechanism is proposed which can maximize stability by minimizing production of such unoccupied sites. This mechanism probably acts in stabilizing E. coli lysogenic for λ. The role of DNA replication in the maintenance of developmental stability and in changes of differentiation is discussed.
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