Catabolic efficiency of aerobic glycolysis: The Warburg effect revisited |
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| Authors: | Alexei Vazquez Jiangxia Liu Yi Zhou Zoltán N Oltvai |
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| Affiliation: | (1) Department of Radiation Oncology, The Cancer Institute of New Jersey and UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08963, USA;(2) Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA |
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| Abstract: | Background Cancer cells simultaneously exhibit glycolysis with lactate secretion and mitochondrial respiration even in the presence of oxygen, a phenomenon known as the Warburg effect. The maintenance of this mixed metabolic phenotype is seemingly counterintuitive given that aerobic glycolysis is far less efficient in terms of ATP yield per moles of glucose than mitochondrial respiration. |
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