Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by Nectin-1/HveC |
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| Authors: | Richart Sarah M Simpson Scott A Krummenacher Claude Whitbeck J Charles Pizer Lewis I Cohen Gary H Eisenberg Roselyn J Wilcox Christine L |
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| Institution: | Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA. |
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| Abstract: | Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons. |
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