Thirteenfold increase of chromosomal aberrations non-randomly distributed in chagasic children treated with nifurtimox |
| |
| Authors: | N B Gorla O S Ledesma G P Barbieri I B Larripa |
| |
| Institution: | Sección Citogenética, Academia Nacional de Medicina, Buenos Aires, Argentina. |
| |
| Abstract: | Chromosomal aberrations were analyzed from cultures of peripheral lymphocytes in 2 groups of chagasic children, before and after treatment with nifurtimox. The mean incidence of chromosomal aberrations increased from control values of 1.75 +/- 1.39 (8 patients) to 23.55 +/- 9.55 (6 patients) at a significance of P less than 0.0001. G-banding analysis of chromosomal aberration sites revealed that treated patients present coincidence in the chromosome regions affected: 1p11, 1q11-12, 9q11-13, 17q11-21, 2p21, 2q23, 2q31, 2q33, 6p21, 6p21, 7q32, 13q14, 13q22, 15q22. These data indicate a non-random distribution of chromosomal aberrations induced by nifurtimox therapeutic treatment. |
| |
| Keywords: | |
|
|
