Lectinomics I. Relevance of exogenous plant lectins in biomedical diagnostics |
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| Authors: | Danica Mislovičová Peter Gemeiner Anna Kozarova Tibor Kožár |
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| Affiliation: | (1) Department of Glycobiotechnology, Center for Glycomics, Institute of Chemistry, Slovak Academy of Science, Dúbravská cesta 9, SK-84538 Bratislava, Slovakia;(2) Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, N9B 3P4, Canada;(3) Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences, SK-04541 Košice, Slovakia |
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| Abstract: | This review focuses on utilization of plant lectins as medical diagnostic reagents and tools. The lectin-related diagnostic is aimed at detection of several diseases connected to alteration of the glycosylation profiles of cells and at identification of microbial and viral agents in clinical microbiology. Certain lectins, proposed for or used as diagnostic tools could even recognize those cellular determinants, which are not detected by available antibodies. Broad information is presented on the lectinomics field, illustrating that lectin diagnostics might become practical alternative to antibody-based diagnostic products. In addition, the rising trend of lectin utilization in biomedical diagnostics might initiate a development of innovative methods based on better analytical technologies. Lectin microarray, a rapid and simple methodology, can be viewed as an example for such initiative. This technology could provide simple and efficient screening tools for analysis of glycosylation patterns in biological samples (cellular extracts, tissues and the whole cells), allowing thus personalized detection of changes associated with carbohydrate-related diseases. |
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| Keywords: | plant lectins diagnostic tool alteration of glycosylation saccharide specificity biomedical application |
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