Inhibition of Human Immunodeficiency Virus Type-1 (HIV-1) Replication by Immunor (Im28), a New Analog of Dehydroepiandrosterone |
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| Authors: | Karidia Diallo Hugues Loemba Maureen Oliveira Donatien D Mavoungoua Mark A Wainberg |
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| Institution: | 1. McGill AIDS Centre, Jewish General Hospital, 3755 Cote Ste-Catherine Road, Montreal (Quebec) CANADA FI3T 1E2;2. Ventre de Recherches sur les pathologies hormonales (CRPH) , BP 1234 , Libreville , Gabon |
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| Abstract: | Abstract The inhibition of' HIV-I replication in vitro by Immunor 28 (IM28), an analog of dehydroepiandrosterone (DHEA), was monitored using the HIV- 1 laboratory wild-type strain IIIB. Evaluation of the 50% inhibitory dose (IC50) revealed a decrease in HIV-1 replication giving an IC, value around 22 μM. The toxicity of the drug has been determined also, in MT2 cells and PBMCs. 60 μM of IM28 provoked a 50% decrease in cell viability while DHEA caused the same decrease at 75 μM in MT2 cells. These values are 125 μM for IM28 in PBMCs and 135 μM for DIIBA. Thus, DHEA is less toxic than IM28, but IM28 has a higher antiviral activity. |
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