A New Synthesis of the Potent and Selective Anti-Herpesvirus Agent (S)-1-[3-Hydroxy-2-(Phosphonylmethoxy)Propyl]Cytosine |
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| Authors: | Joanne J Bronson Louis M Ferrara Henry G Howell Paul R Brodfuehrer John C Martin |
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| Institution: | 1. Bristol-Myers Squibb, Pharmaceutical Research and Development Division, Antiinfective Chemistry Department , 5 Research Parkway, Wallingford, Connecticut, 06492-7660;2. Chemical Process Development Department , Syracuse, New York, 13221-4755 |
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| Abstract: | Abstract A new synthetic approach to (S)-1-3-hydroxy-2-(phosphonyl-methoxy)propyl]cytosine (3, (S)-HPMPC) is based on coupling of the heterocyclic moiety with a glycerol-derived side chain, followed by introduction of the phosphonylmethyl ether group. |
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