Synthesis of New 9-glycosyl-4,9-dihydropyrano [3,4-b]indole-1(3H)-ones as Antibacterial Agents |
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| Authors: | Shaymaa E. Kassab Gehan H. Hegazy Nahed M. Eid Kamelia M. Amin Adel A. El-Gendy |
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| Affiliation: | 1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Misr International University , Cairo, Egypt;2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Cairo University , Cairo, Egypt |
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| Abstract: | A series of new 9-glycosyl-4,9-dihydropyrano[3,4-b]indole-1(3H)-ones 3 was synthesized in moderate to low yields. 4,9-Dihydropyrano[3,4-b]indole-1(3H)-ones (1) were coupled with different acetobromoglycopyranoses 2 in refluxing toluene in the presence of silver oxide to afford one coupling product of the respective N-glycosides. α-L-Arabinopyranosides 3j and 3m were the most active glycosides among the tested compounds against certain Gram positive and Gram negative bacterial strains. |
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| Keywords: | Pyranoindoles N-Glycosylpyranoindoles antibacterial agents |
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