Synthesis and Antitumor Activity of a Heterodinucleotide of BVDU and Gemcitabine |
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| Authors: | L. Cappellacci P. Franchetti P. Vita R. Petrelli M. Grifantini |
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| Affiliation: | Department of Chemical Sciences , University of Camerino , Camerino, Italy |
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| Abstract: | ![]()
A heterodinucleotide comprising BVDU and Gemcitabine bound together by a 5′,5′-pyrophospate bridge (BVDUp2dFdC) has been synthesized and evaluated as antitumor agent against AH13 rat sarcoma cells. BVDUp2dFdC showed a cytotoxicity similar to that of Gemcitabine. |
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| Keywords: | BVDU gemcitabine dinucleotides antitumor activity |
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