Delayed Treatment Effects of Xanthine Oxidase Inhibition on Systolic Overload-Induced Left Ventricular Hypertrophy and Dysfunction |
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| Authors: | X Xu L Zhao X Hu P Zhang J Wessale R Bache |
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| Institution: | 1. University of Minnesota, The Center of Vascular Biology and Cardiovascular Division , Department of Medicine , Minneapolis, Minnesota, USA;2. Takeda Global Research &3. Development Center, Inc. , Deerfield, Illinois, USA |
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| Abstract: | The nonpurine selective xanthine oxidase (XO) inhibitor febuxostat attenuates development of left ventricular (LV) hypertrophy and dysfunction in mice when treatment is initiated within 1 hour of transverse aortic constriction (TAC). This study investigated whether a 7-day delay of treatment with the XO inhibitors febuxostat or allopurinol would reverse TAC-induced changes after onset of heart failure (HF). Neither treatment significantly affected TAC-induced LV hypertrophy; only febuxostat caused a modest improvement in LV function (～10% increase in LV ejection fraction). However, the purine analog allopurinol tended to increase mortality compared with vehicle or febuxostat in HF mice. |
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| Keywords: | Febuxostat allopurinol heart failure left ventricular dysfunction |
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