The Influences of A Nitrogen Atom Position in Dinucleoside 2-,3-,4-Pyridylphosphonates on Fragmentation Patterns in Electrospray Ionization Multistage Tandem Mass Spectra |
| |
| Authors: | Sanhao Ji Yong Ju Hua Fu Yufen Zhao Tommy Johansson Jacek Stawinski |
| |
| Institution: | 1. Key Laboratory of Bioorganic Phosphorus Chemistry &2. Chemical Biology, Department of Chemistry , Tsinghua University , Beijing, China;3. Department of Organic Chemistry, Arrhenius Laboratory , Stockholm University , Stockholm, Sweden |
| |
| Abstract: | 2-,3-,4-Pyridylphosphonates and their phosphonothioate congeners were analyzed by electrospray ionization multistage tandem mass spectrometry (ESI-MSn). It was found that the fragmentation pathways of these compounds were not influenced to any detectable extent by the stereochemistry at the phosphorus centers but were sensitive to the position of a nitrogen atom in the pyridine ring of these compounds. Possible mechanisms for fragmentations of the investigated compounds are discussed in detail. |
| |
| Keywords: | Pyridylphosphonates Pyridylphosphonothioates Nitrogen atom Pyridyl ring Electrospray ionization spectrometry (ESI) |
|
|
