1,4-Benzodiazepine peripheral cholecystokinin (CCK-A) receptor agonists |
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| Authors: | Sherrill R G Berman J M Birkemo L Croom D K Dezube M Ervin G N Grizzle M K James M K Johnson M F Queen K L Rimele T J Vanmiddlesworth F Sugg E E |
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| Affiliation: | Department of Medicinal Chemistry, Glaxo Welcome Research and Development, Research Triangle Park, NC 27709, USA. rgs13254@glaxowellcome.com |
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| Abstract: | 
A series of 1,4-benzodiazepines, N-1-substituted with an N-isopropyl-N-phenylacetamide moiety, was synthesized and screened for CCK-A agonist activity. In vitro agonist activity on isolated guinea pig gallbladder along with in vivo induction of satiety following intraperitoneal administration in a rat feeding assay was demonstrated. |
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