Association between antibody response against cytomegalovirus strain-specific glycoprotein H epitopes and HLA-DR |
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| Authors: | Kei Ishibashi Tadahiko Tokumoto Hiroki Shirakawa Koichi Hashimoto Nobuhiro Kushida Tomohiko Yanagida Keiichi Shishido Ken Aikawa Osamu Yamaguchi Hiroshi Toma Kazunari Tanabe Tatsuo Suzutani |
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| Institution: | Department of Urology;, Department of Microbiology;and Department of Pediatrics, Fukushima Medical University, Fukushima;and Department of Urology, Tokyo Women's Medical University, Tokyo |
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| Abstract: | The gH of CMV is a major target for strain-specific neutralizing antibodies. To verify whether there is a correlation between HLA-DR type and strain-specific antibodies, antibodies against CMV gH in potential donors and recipients for renal transplantation were investigated. Among 471 subjects, 404 (86%) showed reactivity to CMV gH, but no antibodies against gH were detected in 67 (14%) subjects. The positive rates were over 80% in most HLA subpopulations. Fewer subjects with HLA-DR10 and DR11 had antibodies to CMV gH than did those without HLA-DR10 and DR11. HLA-DR10 and DR11 may be associated with fewer/non-responders for strain-specific neutralizing antibodies. |
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| Keywords: | antibody cytomegalovirus glycoprotein H HLA-DR |
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