The L7/L12 proteins change their conformation upon interaction of EF-G with ribosomes |
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| Authors: | A T Gudkov G M Gongadze |
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| Institution: | Institute of Protein Research, Academy of Sciences of the USSR, Pushchino, Moscow Region, USSR |
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| Abstract: | The different functional complexes of ribosomes with elongation factor F (EF-G) were studied by digestion experiments with trypsin. It was found that upon interaction of EF-G with ribosomes the L7/L12 proteins are sensitive to trypsin and are trypsin resistant after dissociation of EF-G from ribosomes. The significance of conformational alterations in the L7/L12 and also in the other proteins in the translation process is discussed. |
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| Keywords: | L7/L12 ribosomal protein Elongation factor G Ribosome trypsinolysis Translation |
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