Replicated associations of <Emphasis Type="Italic">TNFAIP3</Emphasis>, <Emphasis Type="Italic">TNIP1</Emphasis> and <Emphasis Type="Italic">ETS1</Emphasis> with systemic lupus erythematosus in a southwestern Chinese population |
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| Authors: | Hua Zhong Xiao-lan Li Ming Li Li-xia Hao Rong-wei Chen Kun Xiang Xue-bin Qi Runlin Z Ma Bing Su |
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| Institution: | (1) State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China;(2) Department of Dermatology and Rheumatology, The Affiliated Yan’an Hospital of Kunming Medical University, Kunming, Yunnan, 650051, China;(3) Kunming Medical University, Kunming, Yunnan, 650500, China;(4) State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China;(5) Graduate School of Chinese Academy of Sciences, Beijing, 100080, China |
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| Abstract: | Introduction Recent genome-wide and candidate gene association studies in large numbers of systemic lupus erythematosus (SLE) patients
have suggested approximately 30 susceptibility genes. These genes are involved in three types of biological processes, including
immune complex processing, toll-like receptor function and type I interferon production, and immune signal transduction in
lymphocytes, and they may contribute to the pathogenesis of SLE. To better understand the genetic risk factors of SLE, we
investigated the associations of seven SLE susceptibility genes in a Chinese population, including FCGR3A, FCGR2A, TNFAIP3, TLR9, TREX1, ETS1 and TNIP1. |
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