Concomitant synthesis and degradation of glutamine in isolated rabbit kidney tubules |
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| Authors: | S Dugelay G Baverel |
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| Affiliation: | Laboratoire de Physiologie Rénale et Métabolique, CNRS URA 1177 et INSERM U 80, Lyon, France. |
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| Abstract: | When rabbit kidney tubules were incubated with 1 mM [1-14C]glutamine as substrate, a release of 14CO2 together with a net production of glutamine were observed. That glutamine utilization was masked by higher rates of concomitant glutamine synthesis was demonstrated by: (i) inhibiting glutamine synthesis; and (ii) measuring the specific radioactivity of [1-14C]glutamine which fell during incubation. |
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